Henn Lab for Population Genetics
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Publications

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  1. C Uren, M Kim, AR Martin, D Bobo, CR Gignoux, PDV Helden, M Möller, EG Hoal*, BM Henn*. (2016) Fine-scale human population structure in southern Africa reflects ecogeographic boundaries. (in press, Genetics).
  2. BM Henn*, LR Botigué*, S Peishl*, I Dupanloup, M Lipatov, BK Maples, AR Martin, S Musharoff, H Cann, M Snyder, L Excoffier*, JM Kidd*, CD Bustamante* (2016) Distance from Sub-Saharan Africa Predicts Mutational Load in Diverse Human Genomes. PNAS 113(4): E440-E449.
  3. G Hilton, PJ Norman, N Nemat-Gorgani, A Goyos, JA Hollenbach, BM Henn, CR Gignoux, LA Guethlein, P Parham. (2015) Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population. PLoS Genetics 11(8): e1005439
  4. PH Sudmant, S Mallick, BJ Nelson, F Hormozdiari, N Krumm, J Huddleston, BP Coe, C Baker, S Nordenfelt, M Bamshad, LB Jorde, OL Posukh, H Sahakyan, WS Watkins, L Yepiskoposyan, MS Abdullah, CM Bravi, C Capelli, T Hervig, JTS Wee, C Tyler-Smith, GV Driem, IG Romero, A R Jha, S Karachanak-Yankova, D Toncheva, D Comas, BM Henn, T Kivisild, A Ruiz-Linares, A Sajantila, E Metspalu, J Parik, R Villems, EB Starikovskaya, G Ayodo, CM Beall, AD Rienzo, MF Hammer, R Khusainova, E Khusnutdinova, W Klitz, C Winkler, D Labuda, M Metspalu, SA Tishkoff, S Dryomov, R Sukernik, N Patterson, D Reich, EE Eichler (2015). Global diversity, population stratification, and selection of human copy-number variation. Science 349(6253): aab3761.
  5. BM Henn, LR Botigué, CD Bustamante, AG Clark, S Gravel. (2015) Estimating the Mutation Load from Human Genomes. Nature Reviews Genetics. 16(6): 333-343.
  6. I Lazaridis, N Patterson, A Mittnik, G Renaud, S Mallick, PH Sudmant, JG Schraiber, S Castellano, K Kirsanow, C Economou, R Bollongino, Q Fu, K Bos, S Nordenfelt, C Filippo, K Prüfer, S Sawyer, C Posth, W Haak, F Hallgren, E Fornander, G Ayodo, HA Babiker, E Balanovska, O Balanovsky, H Ben-Ami, J Bene, F Berrada, F Brisighelli, GBJ Busby, F Cali, M Churnosov, DEC Cole, L Damba, D Delsate, GV Driem, S Dryomov, SA Fedorova, M Francken, I Romero, M Gubina, JM Guinet, M Hammer, BM Henn, T Helvig, U Hodoglugil, AR Jha, R Kittles, E Khusnutdinova, T Kivisild, V Kučinskas, R Khusainova, A Kushniarevich, L Laredj, S Litvinov, RW Mahley, B Melegh, E Metspalu, J Mountain, T Nyambo, L Osipova, J Parik, F Platonov, OL Posukh, V Romano, I Rudan, R Ruizbakiev, H Sahakyan, A Salas, EB Starikovskaya, A Tarekegn, D Toncheva, S Turdikulova, I Uktveryte, O Utevska, M Voevoda, J Wahl, P Zalloua, L Yepiskoposyan, T Zemunik, A Cooper, C Capelli, MG Thomas, SA Tishkoff, L Singh, K Thangaraj, R Villems, D Comas, R Sukernik, M Metspalu, M Meyer, EE Eichler, J Burger, M Slatkin, S Pääbo, J Kelso, D Reich, J Krause. (2014) Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature 503:409-413.
  7. AR Martin*, HA Costa*, T Lappalainen, BM Henn, JM Kidd, MC Yee, F Grubert, HM Cann, M Snyder, SB Montgomery, CD Bustamante (2014) Analysis of Diverse Human Transcriptomes Reveals Differentiated Regulatory Architecture. PLoS Genetics 10(8): e1004549
  8. JM Kidd*, TJ Sharpton*, D Bobo, PJ Norman, AR Martin, ML Carpenter, M Sikora, CR Gignoux, N Nemat-Gorgani, A Adams, M Guadalupe, X Guo, Q Feng, Y Li, X Liu, P Parham, EG Hoal, MW Feldman, KS Pollard, JD Wall, CD Bustamante, BM Henn (2014) Exome capture from saliva produces high quality genomic and metagenomic data. BMC Genomics 15:262
  9. M Sikora, ML Carpenter, A Moreno-Estrada, BM Henn, PA Underhill, F Sánchez-Quinto, I Zarac, M Pitzalis, C Sidore, F Busonero, A Maschio, A Angius, C Jones, J Mendoza-Revilla, G Nekhrizovh, D Dimitrovah, N Theodossievi, TT Harkins, A Keller, F Maixner, A Zinkl, G Abecasis, S Sanna, F Cucca, CD Bustamante (2014) Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe. PLoS Genetics 10(5): e1004353
  10. M Daya, LVD Merwe, U Galal, M Moller, M Salie, E Chimusa, JM Galanter, PV Helden, BM Henn, CR Gignoux, E Hoal. (2013) A Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Population. PLoS One 8(12): e82224
  11. ER Chimusa, M Daya, M Möller, Raj Ramesar, BM Henn, PD van Helden, NJ Mulder, EG Hoal. (2013) Determining Ancestry Proportions in Complex Admixture Scenarios in South Africa Using a Novel Proxy Ancestry Selection Method. PLoS One 8(9): e73971
  12. GD Poznik, BM Henn, MC Yee, E Sliwerska, GM Euskirchen, AA Lin, M Snyder, L Quintana-Murci, JM Kidd, PA Underhill, CD Bustamante (2013) Sequencing Y Chromosomes Resolves Discrepancy in Time to Common Ancestor of Males versus Females. Science 341(6145):562-565
  13. LR Botigué*, BM Henn*, S Gravel, BK Maples, CR Gignoux, E Corona, G Atzmon, E Burns, H Ostrer, C Flores, J Bertranpetit, D Comas, CD Bustamante. Gene flow from North Africa contributes to differential human genetic diversity in Southern Europe (2013) Proc Natl Acad Sci 110(29): 11791-6.
  14. AM Casto, BM Henn, JM Kidd, CD Bustamante, MW Feldman. (2013) EDA2R/AR Intergenic Region is the Most Divergent Genomic Segment between Africans and Asians in the Human Genome. Hum Biol 84(6): 641-694
  15. BM Henn, LL Cavalli-Sforza, MW Feldman. (2012) The Great Human Expansion. Proc Natl Acad Sci. 109(44):17758-17764
  16. J Granka, BM Henn, CR Gignoux, JM Kidd, CD Bustamante, MW Feldman. (2012) Limited Evidence for Classic Selective Sweeps in African Populations. Genetics 192: 1049-1064
  17. JK Pickrell, N Patterson, C Barbieri, F Berthold, L Gerlach, M Lipson, P Loh, T Güldemann, B Kure, SW Mpoloka, H Nakagawa, C Naumann, JL Mountain, CD Bustamante, B Berger, BM Henn, M Stoneking, D Reich, B Pakendorf. (2012) The genetic prehistory of southern Africa. Nature Comm 3:1143.
  18. CL Campbell, PF Palamara, M Dubrovsky, LR Botigué, M Fellous, G Atzmon, C Oddoux, A Pearlman, L Hao, BM Henn, E Burns, CD Bustamante, D Comas, E Friedman, I Pe’er, H Ostrer (2012) North African Jewish and non-Jewish populations form distinctive, orthogonal clusters. Proc Natl Acad Sci. 109(34):13865-13870
  19. BM Henn*, L Hon*, JM Macpherson, N Eriksson, S Saxonov, I Pe’er, JL Mountain (2012) Cryptic Distant Relatives are Common in both Isolated and Cosmopolitan Genetic Samples. PLoS One 7 (4): e34267
  20. A Keller, A Graefen, M Ball, M Matzas, V Boisguerin, F Maixner, P Leidinger, R Khairat, A Franke, J Mayer, J Spangler, S McLaughlin, M Shah, C Lee, TT Harkins, A Sartori, A Moreno-Estrada, B Henn, PA Underhill, J Chiaroni, M Sikora, CD Bustamante, EE Vigl, M Samadelli, G Cipollini, J Haas, H Katus, B Meder, N Blin, E Meese, CM Pusch, A Zink. (2012) New Insights into the Tyrolean Iceman’s Origin and Phenotype as Inferred by Whole-Genome Sequencing. Nature Comm 3:698
  21. BM Henn*, L Rodríguez-Botigué*, S Gravel, W Wang, A Brisbin, JK Byrnes, K Fadhlaoui-Zid, PA Zalloua, A Moreno, J Bertranpetit, CD Bustamante, D Comas (2012) Genomic Ancestry of North Africans Supports Back-to-Africa Migrations. PLoS Genetics 8(1): e1002397
  22. S Gravel, BM Henn, R Gutenkunst, AR Indap, GT Marth, AG Clark, 1000 Genomes Consortium, CD Bustamante (2011) Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci. 108(29): 11983-11988
  23. CR Gignoux*, BM Henn*, JL Mountain (2011) Rapid, global demographic expansions after the origins of agriculture. Proc Natl Acad Sci. 108(15): 6044-6049. PMCID: 3076817
  24. BM Henn, CD Bustamante, JL Mountain, MW Feldman (2011) Reply to Hublin and Klein: Locating a geographic point of dispersion in Africa for contemporary humans. Proc Natl Acad Sci. 108(28): E278
  25. BM Henn, CR Gignoux, M Jobin, JM Granka, JM Macpherson, JM Kidd, L Rodríguez-Botigué, S Ramachandran, L Hon, A Brisbin, AA Lin, PA Underhill, D Comas, KK Kidd, P Parham, PJ Norman, CD Bustamante, JL Mountain, MW Feldman. (2011) Feature Article: Hunter-gatherer genomic diversity suggests a southern African origin for modern humans. Proc Natl Acad Sci. 108(13): 5154-5162. PMCID: 3069156
  26. CD Bustamante and BM Henn (2010) Human Origins: Shadows of early migrations. Nature 468(7327): 1044-1045. PMID: 21179156
  27. BM Henn, S Gravel, A Moreno-Estrada, S Acevedo, CD Bustamante. (2010) Fine-scale population structure and the era of next-generation sequencing. Hum Mol Genet. 19(2): R221-R226. PMCID: 2953744
  28. J Chiaroni, RJ King, NM Myres, BM Henn, A Ducourneau, MJ Mitchell, G Boetsch, I Sheikha, AA Lin, M Nik-Ahd, J Ahmad, F Lattanzi, RJ Herrera, ME Ibrahim, A Brody, O Semino, T Kivisild and PA Underhill. (2009) The emergence of Y- chromosome haplogroup J1e among Arabic-speaking populations. Eur J Hum Genet. 18(3): 348-53. PMCID: 2987219
  29. BM Henn, CR Gignoux, MW Feldman and JL Mountain. (2009) Characterizing the time- dependency of human mitochondrial DNA mutation rate estimates. Mol Biol Evol. 26(1): 217-230. PMID: 18984905
  30. BM Henn, C Gignoux, AA Lin, PJ Oefner, P Shen, R Scozzari, F Cruciani, SA Tishkoff, JL Mountain and PA Underhill. (2008) Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa. Proc Natl Acad Sci. 105(31): 10692-10297. PMCID: 2504844
  31. SA Tishkoff, MK Gonder, BM Henn, H Mortensen, A Knight, C Gignoux, N Fernandopulle, G Lema, TB Nyambo, U Ramakrishnan, FA Reed, and JL Mountain (2007) History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation. Mol Biol Evol. 24(10): 2180-2192. PMID: 17656633
  32. A Knight, PA Underhill, HM Mortensen, LA Zhivotovsky, AA Lin, BM Henn, D Louis, M Ruhlen, and JL Mountain (2003) African Y chromosome and mtDNA divergence provides insight into the history of click languages. Current Biol. 13(6): 464-473. PMID: 12646128